| Move-boosting items |
| The Charcoal can be found in Cinnabar Mansion, and has a 10% chance to be held by wild Magmar. |
| The Mystic Water can be found in Route 24, and has a 10% chance to be held by wild Psyduck and Golduck. |
| The Miracle Seed can be found in Celadon City, and has a 10% chance to be held by wild Oddish, Gloom, Vileplume and Bellossom. |
| The Silk Scarf can be found in Pewter City, and it has a 10% chance to be held by wild Meowth and Persian. |
| The Black Belt can be found in Rock Tunnel, it has a 10% chance to be held by wild Mankey and Primeape, and it is always held by the Pokémon Black Belts use. |
| The Twisted Spoon can be found in Route 8, and it has a 10% chance to be held by wild Kadabra. |
| The Black Glasses can be found in Team Rocket’s Hideout. |
| The Silver Powder can be found in Viridian Forest, and it has a 10% chance to be held by wild Caterpie and Butterfree. |
| The Soft Sand can be found in Route 19, and it has a 10% chance to be held by wild Sandshrew and Sandslash. |
| The Poison Barb can be found in Route 14, and it has a 10% chance to be held by wild Weedle and Beedrill. |
| The Dragon Fang can be found in Victory Road. |
| The Spell Tag can be found in Pokémon Tower, and it has a 10% chance to be held by wild Haunter and Gengar. |
| The Sharp Beak can be found in Route 18, and it has a 10% chance to be held by wild Spearow and Fearow. |
| The Magnet can be found in Route 11, and it has a 10% chance to be held by wild Magneton. |
| The Never-Melt Ice can be found in Seafoam Islands, and it has a 10% chance to be held by wild Seel and Dewgong. |
| The Metal Coat can be found in Silph Company and the Power Plant, and it has a 10% chance to be held by wild Magnemite. |
| Evolution items |
| The Sun Stone and the Moon Stone can be bought in the Celadon Department Store. |
| One Metal Coat can be found in Silph Company and one can be found in the Power Plant, it has a 10% chance to be held by wild Magnemite, and it is always held by the Scyther traded to the player in Cinnabar Lab. |
| One King’s Rock can be found in Route 12 and one can be found in the Safari Zone, it has a 10% chance to be held by wild Slowpoke, Slowking, Poliwag and Politoed, and it is always held by the Lapras traded to the player in Cinnabar Lab. |
| The Dragon Scale can be found in Seafoam Islands, it has a 10% chance to be held by wild Horsea, Seadra and Kingdra, and it is always held by the Seadra traded to the player in Cinnabar Lab. |
| The Up-Grade is given to the player by the Silph Company secretary after defeating Giovanni and running Team Rocket out of the building. |
| Other items |
| Ethers and Elixirs can now be bought at the Pokémon League. |
| The Lucky Egg is always held by the Chansey traded to the player in Route 18. |
| The Light Ball has a 10% chance to be held by wild Pichu and Pikachu. |
| TM32 Earth Power can be found in the Safari Zone. |
| TM36 Sludge Bomb can be found in Silph Company. |
| TM41 Heat Wave can be found in Silph Company. |
| TM45 Poison Jab can be found in Cinnabar Mansion. |
| TM49 Dark Pulse can be found in Team Rocket’s Hideout. |
